Since I spent hours and hours tracing the known RA MB carriers to an old 1900 black bull, and was 100% sure that all the pieces fit together, I was dismayed that the original report from Dr B was that the mutations in the Angus and Red Angus were not the same and that the test for marble bone in RA does not work for blacks
BUT WAIT - turns out the black calf that was thought to be a marble bone calf - whose tissues were used to test for the mutation in blacks - did not have marble bone (sort of like looking for a red gene in a homozygous black bull) so THE ANSWER IS...
The frequency of MB in blacks is EXTREMELY LOW
The mutation is the SAME
The RA test will work on blacks
and the pedigree hunt is probably accurate
This shows the importance of accurate pathological diagnosis when basing gene hunts of phenotype
BUT WAIT - turns out the black calf that was thought to be a marble bone calf - whose tissues were used to test for the mutation in blacks - did not have marble bone (sort of like looking for a red gene in a homozygous black bull) so THE ANSWER IS...
The frequency of MB in blacks is EXTREMELY LOW
The mutation is the SAME
The RA test will work on blacks
and the pedigree hunt is probably accurate
This shows the importance of accurate pathological diagnosis when basing gene hunts of phenotype