double muscling

[knabe]

hadn't noticed this before.

maine's have two of the disruptive types.

http://us.igenity.com/pdfs/forms/Igenity%20Results%20Key%20Beef.pdf

Myostatin
Myostatin, as part of the IGENITY Profile, analyses for nine different variants of the myostatin gene, even though some may not be found all breeds.
Six variants are classified as “disruptive;” these cause muscle hypertrophy (double-muscling), larger birth weights, increased dystocia and enhanced tenderness.
Three myostatin variants are referred to as “missense,” and will increase muscularity and reduce external and intramuscular fat, with no change in birth weight.
For all myostatin variants one copy is intermediate.
Disruptive variants are: Missence variants are:
C313Y nt419                      D182N
E226X nt821                      F94L
E291X Q204x                    S105C
Myostatin results are reported as:
0 None of the nine possible variants are present
1, Variant One copy of the listed variant is present
2, Variant two copies of the listed variant are present

 

[simtal]

what about tenderness? still bad i suppose. 

waygu cross?

 

[HerefordGuy]

This is great Knabe, thanks for sharing.  With recent advances in sequencing and SNP chips, these marker panels are only going to get better.  Very exciting time in animal breeding.  (clapping)

 

[AAOK]

In my 17 years of breeding high % Maine-Anjou I produce one double muscled calf; FR Magic sire X Patriot x Administrtor Dam.  The bull calf also rolled over at the knee in both front legs.  I got the little rascal up to 1100 pounds while he could still get up and down.  Best meat we ever put in the freezer.

 

[knabe]

In my 17 years of breeding high % Maine-Anjou I produce one double muscled calf; FR Magic sire X Patriot x Administrtor Dam.  The bull calf also rolled over at the knee in both front legs.  I got the little rascal up to 1100 pounds while he could still get up and down.  Best meat we ever put in the freezer.

that is really annoying.

on the face of it, smithbuilt was linebred with supposedly no faults, and i'd hadn't heard either epinal or cunia were double muscle carriers who fill out the cow side of magic.  that means magic may have two faults? potentially SP and DM.  if smithbuilt is a carrier and epinal and touchdown are not, that narrows down a troubling bit of a theory i've had for a while.

was bysantin a double muscle carrier?  this thread might make me cry.  i guess that's ok. i have a way out. but it will have to be verified.  dang, more testing.  hmm.  maybe double muscling was an early quiet exit for some of the early maine's.

was covino III a carrier?

 

[shortyjock89]

I know it's in Shorthorns too, we had two calves born with it two years ago, out of the same bull, and vastly different pedigrees on the dam side.  The bull was a Waukaru Goldmine 2109 x IWF Magic. The cows were by JA Wellington and RB Eagle 148 (all thought Eagle bulls were SUPER heavy muscled, diluted Double Muscling? Especially Eagle 256).  Maybe there is a link between the Maine and Shorthorn DM.

 

[knabe]

diluted Double Muscling?

that is one theory, ie a continuous.

since there are two forms in maine's, it might be more annoying.  they both truncate about a third in in the protein. not as early as the limi one, which is bp94.  need to double check.

 

[farmboy]

we had two calves in a row from the same bull same cow. both bull calves. very muscular like their quarters were exploding and they had big muscular toplines, i think they were double muscled.. we just put one in the freezer a few weeks ago. the meat is as good as i can remember anything we have ever had. the bull was a pale face angus and the cow was half shorthorn and some maine in her.

 

[stangs13]

I was reading up on limousins and they can carry a form of double muscling, a diluted gene i would guess, dont remember.

 

[knabe]

I was reading up on limousins and they can carry a form of double muscling, a diluted gene i would guess, dont remember.

google this.

F94L

 

[Telos]

Apparently it was the rule of thumb not to report a DM calf to the Maine Assoc.. Would it be great to be able and ask the AMAA for a list of all their DM carriers.

 

[phillse]

Bumping this old thread up since the thread http://www.steerplanet.com/bb/the-big-show/list-of-triple-clean-shorthorn-bulls/ is discussing myostatin genes.

 

[phillse]

hadn't noticed this before.

maine's have two of the disruptive types.

http://us.igenity.com/pdfs/forms/Igenity%20Results%20Key%20Beef.pdf

Myostatin
Myostatin, as part of the IGENITY Profile, analyses for nine different variants of the myostatin gene, even though some may not be found all breeds.
Six variants are classified as “disruptive;” these cause muscle hypertrophy (double-muscling), larger birth weights, increased dystocia and enhanced tenderness.
Three myostatin variants are referred to as “missense,” and will increase muscularity and reduce external and intramuscular fat, with no change in birth weight.
For all myostatin variants one copy is intermediate.
Disruptive variants are: Missence variants are:
C313Y nt419                      D182N
E226X nt821                      F94L
E291X Q204x                    S105C
Myostatin results are reported as:
0 None of the nine possible variants are present
1, Variant One copy of the listed variant is present
2, Variant two copies of the listed variant are present

Can anyone shed any light on the Missence variants? 
They are said to increase muscularity and reduce external and intramuscular fat, with no change in birth weight.
Does anyone have any more information or specifics about these :
D182N
F94L
S105C

 

[Cabanha Santa Isabel - BR]

DM in Shorthorn can came from Chianina and Maines.
UK Shorthorn are full of DM, they used Maine Anjou massivelly as well as some NA genetics with Maine, as Trump on ancestors.
Here, I inspected some calves for register, found 3 DM. Descarded!
Sired by a canadian bull, that show a strong muscle on back.

 

[Willow Springs]

DM in Shorthorn can came from Chianina and Maines.
UK Shorthorn are full of DM, they used Maine Anjou massivelly as well as some NA genetics with Maine, as Trump on ancestors.
Here, I inspected some calves for register, found 3 DM. Descarded!
Sired by a canadian bull, that show a strong muscle on back.

You've got that backwards - my understanding is that the double muscling in the Maines came from the Durham Shorthorn cattle that were used to create the Maine Anjou breed. That is also where the Belgian Blue got there double muscling. So the cattle in the UK may have gotten it from the Maines that were bred back in, but there was probably some still in their own population.

As to the Canadian bulls siring double muscling - yes there are a few known in very popular bloodlines.

 

[aj]

I thought that it was the Angus and Belgium Blue that had the same variation. nt 821.

 

[Cabanha Santa Isabel - BR]

DM in Shorthorn can came from Chianina and Maines.
UK Shorthorn are full of DM, they used Maine Anjou massivelly as well as some NA genetics with Maine, as Trump on ancestors.
Here, I inspected some calves for register, found 3 DM. Descarded!
Sired by a canadian bull, that show a strong muscle on back.

You've got that backwards - my understanding is that the double muscling in the Maines came from the Durham Shorthorn cattle that were used to create the Maine Anjou breed. That is also where the Belgian Blue got there double muscling. So the cattle in the UK may have gotten it from the Maines that were bred back in, but there was probably some still in their own population.

As to the Canadian bulls siring double muscling - yes there are a few known in very popular bloodlines.

Agree, it's possible. As some DM animals are appearing on Normande too. Also can be an atavic gene hidden on European population - France, Belgian and The Netherlands.

By the way, with high influx genetics in and out on Shorthorn, we can reach to a point that to ask ....How was first created, the egg or the chicken?

 

[Duncraggan]

Exactly!
Test, test and test again, that is the only solution.
When you read this you want to go native!

 

[knabe]

maine's have three? variants of DM as 821 is not listed here as being in maines but it has been found. maybe it's in blacks but not fullbloods?  not sure.

http://www.southdevon-cattle.com.au/myostatin.htm

In the course of their research, Grobet et al. (1998) found a cytosine to adenine (C-->A) transversion at nucleotide position 282 in the myostatin gene, which results in the phenylalanine at amino acid position 94 in the myostatin protein being replaced by leucine. This missence variant, known as the F94L mutation, did not disrupt the myostatin protein as did the six loss-of-function mutations described above, but it did interfere with its function, rendering it less effective in controlling muscle growth; as a result, animals with this variant do not exhibit typical double muscling, but they do have an increased muscle mass due an increase in the size of the muscle fibres (but not in their number). This mutation is common in Limousin cattle, but also occurs in South Devon cattle.

C313Y G --> A transition (938)

Substition of cysteine by a tyrosine, leading to an alteration in the three dimensional structure of the protein

Piedmontese

 

[Boreal]

Exactly!
Test, test and test again, that is the only solution.
When you read this you want to go native!

What makes you think natives will be clean? E226X arose 150 years ago - could have been a Native that it originated in. A Native bull tested positive for Th. Genetic mutations can occur randomly in any breed at any time. Genetic mutations, or there absence, do not determine purity.