In our prevention program we have used ALPHA 7 for many years, had a test one year without me knowing it ....Young hired man wasn't giving it and it cost me 40 calves that year and towards the end I checked refrigerator to see if needed more and hardly any was gone on 150 doses ....Worst thing it caused was the coyotes would pick on those sick calves ,and when you start trying to keep calves alive in an epidemic like that you just keep losing a few because of damage from being sick !!! Really hard on lungs ....