TH / PHA

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willow

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Jan 8, 2011
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Ok nobody brow beat me for asking this question, but how much does breeding to a TH or PHA carrier change things in terms of size and BW of the resulting calves.  I know and understand how TH and PHA occur and all the specifics when it comes to that.  We have clean females and have never bred to carrier bulls simply because it scares me a little.  Our cows have big enough babies without adding any other factors to the mix.  I don't want to kill a cow just to have a calf, but I almost think that to be competitive you have to breed to a carrier or your females have to be carriers (correct me if I am wrong).  So someone with some experience in this department enlighten me.  Are there particular cows that you would never consider breeding to a carrier?  If so, why?  I am asking this question because looking at the new sire catalogs this time of year I cannot help but notice the dwindling number of clean bulls. 
 
C

crybaby

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willow said:
I am asking this question because looking at the new sire catalogs this time of year I cannot help but notice the dwindling number of clean bulls. 

all the more reason to make a great clean one yourself.

will being a carrier result in a bigger calf- no, not directly..

indirectly, it could result in a 'better' calf-- meaning stouter and bigger hipped-- that might add to calving difficulty- but not BW...  dont' get the 2 confused...

I'd bet 95% of the steers winning big time- were 120-140 lb at birth, and double carrier.  I'd also wager that a good % of them were created mating a THC to a THC.
 
J

JTM

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There is the theory that carrier cattle are better, more bone, stouter hips, and more thickness. So if this is true, which I hear is, but don't know from experience, then along with breeding to carriers you will more than likely have stouter calves when the calves are carriers. Now add to that the genetics of the carriers to begin with are mostly high birthweight, big boned, etc. I think it's safe to say that the calves will be bigger and stouter and you are taking more of a risk in breeding to that type. They have been specifically selected for certain traits, low birthweight and calving ease aren't among them.
 

twistedhshowstock

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JTM said:
There is the theory that carrier cattle are better, more bone, stouter hips, and more thickness. So if this is true, which I hear is, but don't know from experience, then along with breeding to carriers you will more than likely have stouter calves when the calves are carriers. Now add to that the genetics of the carriers to begin with are mostly high birthweight, big boned, etc. I think it's safe to say that the calves will be bigger and stouter and you are taking more of a risk in breeding to that type. They have been specifically selected for certain traits, low birthweight and calving ease aren't among them.

I think you hit the nail on the head in this statement.  I know many will argue with me, and will tell me I am an idiot and do not know how anything works when I say this. But I have a college education in this type of thing so I am still fairly confident in my stance on it, at the same time I dont claim to be an expert, so I am sure there are experts who could explain it better.  But from my understanding of genetics and how they work.  TH is a mutant gene that affects the tibial development(or the legs if you need laymens terms) and doesnt affect any other part of the body...PHA is a mutant gene affecting the development of the lungs and not any other part of the body.  Both genes are completely recessive, tere is no known codominance in these genes.  Which means if the calf is not omozygous for te gene, then it affects absolutely nothing in the calf, and if it is omosygous then it is lethal.  So if they are carriers then the gene influences development in no way.  Many will say there is a direct tie between these genes and amount of bone, stoutness, amount and quality of hair, etc.  The gene doesnt cause this though as many will argue.  The TH/PHA genes dont make one bigger boned, hairrier,etc.  The correlation between the 2 is that many of the bloodlines that pass these genes just happened to be the ones that were bigger boned, heavier muscled, harrier etc to begin with.    We dont (or shouldnt) breed to these bloodlines wanting these genes.  We breed to them  wanting the positives  such as hair and bone, this mutant gene that often comes along with it is just extra, the muscle, hair and bone dont come because of the gene or visa versa. In my opinion it just goes along with saying, sometimes you have to take the bad with the good.  Unlike many others  I think it is very possible for animals that are carriers and posses all the positives to pass on the positives without the negative(TH/PHA) and in my opinion I think there are plenty of quality double clean specimens out there out of carrier parents to support that.  The reason we see  so man carrier cattle out there winning is one there are a lot of good carriers out there, and many people are breeding these good carriers to other good carriers, doubling the chances that they will produce a carrier,  and doubling chances they will have a lethal calf, and possibly loose the cow in the process.
There are many breeders out there that absolutely will not use a carrier in breeding, because they feel it is immoral to allow the gene to continue.  Then there are those like me, while I feel we should try to eradicate as many genetic deffects as possible, I dont always feel it is immoral  if you allow the gene to pass on.  Many of those breeders, such as myself, will use a carrier but will not  breed carrier to carrier.  We dont do it so much because of our moral feelings, we do it because we are smaller breeders, and want to avaid the loss of a lethal calf, and cant afford the gamble of possibly loosing a good cow in the process.  Regardless of the reason however, I think as more people become concious of these deffects, and many breeds require you to test and report the carrier status(some even go as far as to decline registration to  animals that are carriers of defects) I think you will see more and more good  CLEAN cattle.  Do I think it will ever truly disappear, no, but I do think you will see more clean cattle that are competitive with the carriers. 

In regards to the original posts, I dont know that I see a dwindling number of clean bulls, I think I actually see an increase in quality of clean bulls. But just like the above poster stated,  the gene will not directly cause bigger calves (well except in lethal PHA calves, they tend to be huge as a result)  but at the same time most of the animals that carry the genes also come from bloodlines known for bigger calves, or biger shouldered calves that dont come as easily.

Please forgive me for the tangent.
 

willow

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Thank you all for your comments.  TwistedH...thank you and I your information it is much appreciated.  I guess I have some thinking to do in regards to whether I am willing to take that next step.  However, I know one thing we will never be breeding carriers to carriers because for me that just isn't a potential loss I am willing to take.  Thanks again.
 

twistedhshowstock

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I want to appologize for the gramatical errors in my above tangent.  LOL. For some reason my keyboard last night decided that some of the keys should be touchy.  The joys of an ancient laptop.  Anyway I thought I had caught all the mistakes but just realized there were a lot of missing h's and that was the key giving me the main difficulty.  Through the process I just got frustrated and quit caring about it I guess. 

Guess it is time for an upgrade.
 

R1Livestock

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Twistedshowstock has a very well thought out post that makes a lot of sense.

I still think there are an awful lot of people not on that train, including me.  When you can go out in a pasture of calves and pick out the carriers with alarming frequency, I think you really have to question that being THC doesn't affect them.

Better yet, do a flush and test the offspring.  If there are both tested carriers and non-carrier offspring in the same flush, look at each set and see which are stouter.  It'll open your eyes.
 
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crybaby

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look at the hair split on the heads of carriers...  almost another give away..
 

kidsandkows

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One more thing to consider. I fall into the category of the last two poster's I dont want to breed a carrier to a carrier either....and one thing that has caused that I had not given enough consideration is the testing I have to do. I am not sure how many head you are looking at, but if you mate a carrier to a clean and are thinking of keeping the offspring as a replacement then you would probably need to test that offspring eventually to know what you can breed her to without risking a defect calf. If you are talking about relatively small numbers its probably not a big deal. But it is an increase in managment requirements and costs. I think the tests are $25 for one defect(TH/PHA) or $40 for both? And then if you have carrier bulls/and or multiple cleanup bulls you have to manage pastures and which cows can go in which pasture or with which bull. Just food for thought, hopefully it helps you make an informed decision.

This was a cool thread. Never really thought about it, but from everything I know Twisted you are right. Being a carrier should not have a phenotypical influence unless it is a homozygous in which case it is dead.
 

twistedhshowstock

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R1Livestock said:
Twistedshowstock has a very well thought out post that makes a lot of sense.

I still think there are an awful lot of people not on that train, including me.  When you can go out in a pasture of calves and pick out the carriers with alarming frequency, I think you really have to question that being THC doesn't affect them.

Better yet, do a flush and test the offspring.  If there are both tested carriers and non-carrier offspring in the same flush, look at each set and see which are stouter.  It'll open your eyes.

I am not saying there isnt corelation.  A lot of the carriers also possess the good genes so yes most, but not all carriers are gonna be stout good looking cattle.  We can pick the carriers because the genetics that pass on the gene also pass on the stoutness and hair.  You would have a harder time though going to a pasture and picking out all the clean calves, because there are some that will have the hair and stoutness and not have the gene.  I am not saying there isnt corelation between the two, I am saying that simple genetics tells us that the ene is not what makes them hairier and stouter, which is what a lot of people want to arue. And the fact that it is simply a corelation or coincidence and not the the gene causing this, means that it is possible to create specimens with the stoutness and hair that dont carry the genetic deffect.  Is it oing to happen overniht or everytime, no. But it is possible.  I just et frustrated, because many people are educatin others inproperly. They are leading them to believe that the gene causes it, so some are ready to  give up on being competitive with clean genetics.  And they shouldnt do that, the gene doesnt cause better calves, it just happens that many of the better calves are carriers.  I may be mistaken but wasnt one of the Champ or Reserve  Steers at Denver a year or two ago clean by pedigree.  Even though there were carriers on both sides, both of his parents ot all the positives but not the defect, and they combined to pass on those positives without the defect.  I may be mistaken but seems like I heard that in one of the earlier discussions of that on here.
 
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crybaby

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the TH gene, and hte gene for 'hair' are very closely related-- and most often get passed together.... or atleast that's what Dragon Lady has told us to believe.
 

Barrel Racer

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twistedhshowstock said:
TH is a mutant gene that affects the tibial development(or the legs if you need laymens terms) and doesnt affect any other part of the body...PHA is a mutant gene affecting the development of the lungs and not any other part of the body.  Both genes are completely recessive, tere is no known codominance in these genes.  Which means if the calf is not omozygous for te gene, then it affects absolutely nothing in the calf, and if it is omosygous then it is lethal.  So if they are carriers then the gene influences development in no way.  Many will say there is a direct tie between these genes and amount of bone, stoutness, amount and quality of hair, etc.  The gene doesnt cause this though as many will argue. 

Just want to correct a few things... The mutated gene that causes TH does not affect only tibial development.  It actually is responsible for hind limb formation including the pelvic bones.  Looking back TH should have probably been named something else.  I've gotten TH affected calves that have no tibial malformations.  Their only abnormal characteristic is a severe abdominal hernia.  One was alive and walking around in a feedlot.  This is caused by incomplete fusion of the pelvic bones, and all TH calves I have ever seen have this.  A lot have the tibial issues and then some also have meningocele due to cranial defects.  That being said,  I can see that there could be some differences in the hind limb placement in carriers (this is not scientifically speaking just based on discussions with those who have a lot of experience with carriers).  Now for the amount of hair with carriers.  I honestly can't see anything that would make biological sense located near the gene causing TH.  Not to say it's not there, but right now with the gene functions we know (see PHA explanation later) I don't see anything that would make me connect the two. 
So now on to PHA.  There is very little known on the function of the mutated gene.  Besides the poor lung deveopment, we know that PHA calves have little to no lymphatic system, which explains the huge amount of fluid in the calves.  Prior to our research there was nothing in the human or mouse databases to suggest, this gene was involved in any of these functions.  The gene is conserved in almost all animal species so it does have a very specific and important role in development.
 

R1Livestock

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I might be able to go along with your 'correlation' theory.  Sounds plausible.  But riddle me this,

Heat Wave has a ton of sons out there. A ton of the bulls most would associate with TH--hair, bone and hip.  The THC HW sons outnumber clean HW sons 4 to 1 at least, and probably more than that.

Where are all of the clean HW sons that have hair, bone and hip?  There should at the very least be some of them running around.

It is plausible that people have bought into theory TH means hair and bone, and are therefore biased towards TH cattle.

I believe people are biased towards cattle they find visually pleasing.  This is why TH goes on and on.

On another note, some people purport to be able to visually pick out PH carriers at a good rate.  I'm guessing you all think this is REALLY crazy?
 

knabe

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crybaby said:
all the more reason to make a great clean one yourself.

will being a carrier result in a bigger calf- no, not directly..

indirectly, it could result in a 'better' calf-- meaning stouter and bigger hipped-- that might add to calving difficulty- but not BW...  dont' get the 2 confused...

I'd bet 95% of the steers winning big time- were 120-140 lb at birth, and double carrier.  I'd also wager that a good % of them were created mating a THC to a THC.

you haven't made one, never will.

better get a spreadsheet and plot your theory with actual data.
 

knabe

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kamerkat said:
knabe what took you so long to fig out crybaby was full of bs

been a little busy.  i can't stay on-line all day like he can at nrcs.

i can't decide who to call, the nrcs or the fsa

he kinda reminds me of courtney on the bachelor.
 
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