white heifer disease
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aj
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mark tenenbaum
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British Whites are some of the most wound up linebred cattle on earth-like murry greys but they are about 150 years older as a breed and wound up from day one-they are Shorthorns and they dont have the White heifer deal-which I have only experienced twice-both out of White heifers that went back to AF Deerpark Dividend 932-Like the dwarfs I got and later saw out of a daughter of a KABA LEADERxFULL SIB TO KABA Rose. its like a computer virus-some of the Irish cattle were so inbred whaen they first got here-and then it got intensified -(most recently and similar with the Solution -Trump-on top-Trump-Kaba yata yatta on the bottom-THAT-there are genetic chinks in the armor -and wierd things start to happen, Im going to quote Edward Quane (DEERPARK) when I visited him at his home in Ireland in 1990- "Its come to an end -AND WE HAVE TO HAVE AN OUTCROSS" O0 O0
Cabanha Santa Isabel - BR
Well-known member
I bought and produce many whites on my short history as Shorthorn breeder.
Never had problems with whites.
Whites are my preferred color just with roans!
But, last month received a call from a friend that import with me some embryos from UK.
He got a good white heifer that is totally infertile!
She is free of american blood.
Also show some red ears and muzzle.
Possible a randomical character...some have lucky some not!
Look for a pic of heifer, but none in good position to show her marks.
Never had problems with whites.
Whites are my preferred color just with roans!
But, last month received a call from a friend that import with me some embryos from UK.
He got a good white heifer that is totally infertile!
She is free of american blood.
Also show some red ears and muzzle.
Possible a randomical character...some have lucky some not!
Look for a pic of heifer, but none in good position to show her marks.
Cabanha Santa Isabel - BR
Well-known member
garybob said:
GB...White Angus are not Aberdeen Angus....they are a crossbred!
They are selling a cross with a facticious name!
Medium Rare
Well-known member
Cabanha Santa Isabel - BR said:
Most are, but there are now some "pure" Angus that are white. The results of a single gene splice.
One strain used the leghorn chicken gene, but I guess that qualifies as "GMO". The next strain used the silver galloway gene. I'm not sure if either strain is still being developed for commercial use.
Cabanha Santa Isabel - BR
Well-known member
Medium Rare said:
WHAT!!!!
Chicken genes on cattle!?!?!?!
By the way, Murray are not Aberdeens....OK OK, they are NOW Anguses cousins! ahahahahaha.....but for me MG are yet SHO x AA.
Medium Rare
Well-known member
Cabanha Santa Isabel - BR said:Medium Rare said:
WHAT!!!!
Chicken genes on cattle!?!?!?!
By the way, Murray are not Aberdeens....OK OK, they are NOW Anguses cousins! ahahahahaha.....but for me MG are yet SHO x AA.
I had forgotten about them using the Short hair gene from Senepol cattle. It's crazy what a little gene editing in the lab can do these days.
“So, in the end, we took the white coat from Silver Galloway and the short coat from Senepol cattle and we put both of those onto a champion Black Angus line.”
Read more at http://www.redorbit.com/news/science/1113331105/the-science-behind-white-angus-cattle-an-interview-with-dr-james-west-021015/#It231tVrciOAFIJb.99
librarian
Well-known member
https://www.researchgate.net/publication/276594774_The_Effect_of_a_Coat_Colour-Associated_Genes_Polymorphism_on_Animal_Health_-_A_Review
KITLG (MGF) geneThe KITLG (tyrosine-protein kinase ligand) gene, also called MGF (mast cell growth factor) gene, encodes a tyrosine kinase receptor ligand. Ligand binds to the tyrosine receptor kinase KIT, stimulating migration, proliferation and survival of melanocytes, hematopoietic cells and germ cells (Marklund et al., 1999). KITLG also plays an important role in nerve cells development and mast cells development, migration and function (Scherer and Kumar, 2010). In cattle KITLG gene (localized in locus Roan) was mapped to the telomeric end of BTA5 (Aasland et al., 2000). Roan pattern is common in two cattle breeds, Shorthorn and Belgian Blue. In exon 7 (nucleotide 654) of the KITLG gene, missense mutation was identied (C>A) causing a substitution of alanine by asparagine (Ala193Asp), whereas the asparagine is present in the protein encoded by allele R, and alanine – by allele r. Allele R is responsible for white coat colour, and allele r for the black (in Belgian Blue cattle) or red (in Shorthorn) coat colour (Seitz et al., 1999). These alleles are inherited with incomplete dominance, however, genotype Rr shows incomplete penetration. In both cattle breeds allele R is linked to genital development disorder, characterized by a missing or underdeveloped vagina, cervix or uterus. This disorder syndrome has been named White Heifer Disease (Charlier et al., 1996). Over 90% of affected heifers have white coat colour, and among the remaining 10% blue coloured heifers (Belgian Blue) or roan coloured heifers (Short-horn) predominate
KITLG (MGF) geneThe KITLG (tyrosine-protein kinase ligand) gene, also called MGF (mast cell growth factor) gene, encodes a tyrosine kinase receptor ligand. Ligand binds to the tyrosine receptor kinase KIT, stimulating migration, proliferation and survival of melanocytes, hematopoietic cells and germ cells (Marklund et al., 1999). KITLG also plays an important role in nerve cells development and mast cells development, migration and function (Scherer and Kumar, 2010). In cattle KITLG gene (localized in locus Roan) was mapped to the telomeric end of BTA5 (Aasland et al., 2000). Roan pattern is common in two cattle breeds, Shorthorn and Belgian Blue. In exon 7 (nucleotide 654) of the KITLG gene, missense mutation was identied (C>A) causing a substitution of alanine by asparagine (Ala193Asp), whereas the asparagine is present in the protein encoded by allele R, and alanine – by allele r. Allele R is responsible for white coat colour, and allele r for the black (in Belgian Blue cattle) or red (in Shorthorn) coat colour (Seitz et al., 1999). These alleles are inherited with incomplete dominance, however, genotype Rr shows incomplete penetration. In both cattle breeds allele R is linked to genital development disorder, characterized by a missing or underdeveloped vagina, cervix or uterus. This disorder syndrome has been named White Heifer Disease (Charlier et al., 1996). Over 90% of affected heifers have white coat colour, and among the remaining 10% blue coloured heifers (Belgian Blue) or roan coloured heifers (Short-horn) predominate
librarian
Well-known member
I was studying this KIT gene regulation in breeds that express color sided or lineback pigment patterns. When I read about the gonadal hypoplasia predominantly in white males, it rang a bell with white heifer disease. I wonder if this is the science behind the old shorthorn breeder practice of using white bulls every third generation. I always thought that idea was about heterozygosity and keeping roan strong, but now I believe it was a caution about stacking white.
https://www.sciencedirect.com/science/article/abs/pii/S0093691X97000113
Ovarian hypoplasia in heifers due to germ cell weakness
https://core.ac.uk/download/pdf/43338504.pdf
Ectopic KIT Copy Number Variation Underlies Impaired Migration of Primordial Germ Cells Associated with Gonadal Hypoplasia in Cattle (Bos taurus)
https://www.sciencedirect.com/science/article/abs/pii/S0093691X97000113
Ovarian hypoplasia in heifers due to germ cell weakness
https://core.ac.uk/download/pdf/43338504.pdf
Ectopic KIT Copy Number Variation Underlies Impaired Migration of Primordial Germ Cells Associated with Gonadal Hypoplasia in Cattle (Bos taurus)
aj
Well-known member
Interesting.
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